Careers

Principal Scientist/Associate Director, Discovery DMPK

SUMMARY:

Disc Medicine is searching for a talented Principal Scientist or Associate Director to join Discovery DMPK. The successful candidate will be primarily responsible for representing DMPK to discovery projects all the way from early target validation stages to the nomination of the development compound. The incumbent will be responsible for working with various CROs on the in vitro and in vivo ADME, PK, PKPD, and TK studies and ensure timely data-based decision making within the project teams.  The candidate should have strong understanding of DMPK and PKPD areas applicable to animal models, the translation into humans, and have demonstrated experience leading the discovery projects as the DMPK representative.

RESPONSIBILITIES:

  • Responsible for leading the scientific, technical and operational efforts as the DMPK representative for discovery projects
  • In charge internal and external DMPK activities, including routine studies, study design, results interpretation, troubleshooting, and issue management for the given discovery projects
  • Working with the project teams and CROs on designing and execution of biotransformation and transporter studies and interpretation/communication with the project teams as needed
  • Participating in the IND documentation
  • Responsible for quality, quantity, and timelines of all DMPK and PKPD activities within the project teams

REQUIREMENTS:

  • PhD or MS in Pharmaceutical Sciences, Pharmacokinetics, Drug Metabolism, or a related field with 12+ years’ experience in the pharmaceutical industry
  • Strong scientific knowledge of Drug Discovery, DMPK/ADME, biotransformation, transporters, and PKPD
  • Demonstrated expertise in DMPK and PKPD areas
  • Experience working with CROs
  • Demonstrated expertise in PK and PKPD NCA data analysis using WinNonlin and has the flexibility and experience of supporting both discovery and clinical stage projects
  • Highly desirable to have experience in biotransformation of small molecules and transporters
  • Demonstrated experience in bioanalysis and assay trouble shooting for both drug molecules and PD markers
  • Excellent problem-solving skills, team player with strong inter-personal skills
  • Good written and communication skills

ABOUT DISC MEDICINE:

Disc Medicine is a biopharmaceutical company committed to applying our scientific leadership in hematologic diseases to transform the lives of patients. We are committed to bringing hope to patients who suffer from hematologic diseases through innovation. Our team has built a pipeline of first-in-class therapies that each have the potential to address a wide array of hematologic diseases, ranging from rare genetic disorders to widely prevalent anemias associated with chronic disease.

Interested in joining our team? Please contact us at careers@discmedicine.com

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