Careers

Associate Director/Director, Bioanalytical Lead

COMPANY OVERVIEW:

Disc Medicine is a clinical-stage biopharmaceutical company committed to discovering, developing, and commercializing novel treatments for patients who suffer from serious hematologic diseases. We are building a portfolio of innovative, first-in-class therapeutic candidates that aim to address a wide spectrum of hematologic diseases by targeting fundamental biological pathways of red blood cell biology, specifically heme biosynthesis and iron homeostasis. Disc Medicine values collaboration, professional development, and scientific integrity and promotes an inclusive company culture that empowers and inspires.


POSITION OVERVIEW:

Disc Medicine seeks an Associate Director/Director, Bioanalytical Lead, to join its growing team. In this broad role, the successful candidate will independently serve as the subject matter expert for assigned programs and studies providing solutions to achieve program milestones. Reporting to the Senior Director, Head of Bioanalytical and Biomarker Development, this position offers the chance to join a team of passionate colleagues with robust learning and career growth opportunities.

RESPONSIBILITIES:

  • The technical roles and responsibilities include but are not limited to bioanalytical support for: 
  • discovery and development activities
  • non-GLP and GLP studies
  • small molecules and biologics drugs
  • pre-clinical and clinical studies
  • drugs (PK), biomarkers (PD), and ADA (Immunogenicity).
  • Serve as Bioanalytical liaison between internal teams and CROs for bioanalytical support.
  • Responsible for high-quality reports for regulatory submissions (such as INDs or Common Technical Documents) and implementing a robust quality and compliance program for all bioanalytical work, including compliance with GxP regulations for non-clinical safety and clinical studies.
  • Determine additional bioanalytical requirements if needed and perform regular site visits and inspections.
  • Establish/Follow internal processes/workflows to manage samples, methods, data, reports, contracts, and budgets for studies within the non-clinical development organization.
  • Interact with cross-functional teams within Disc Medicines to provide operational support for non-clinical development studies if needed. 
  • Manage CROs to address operational needs for contracts, samples, data, and reports to meet project timelines.

 REQUIREMENTS:

  • PhD in bioanalytical chemistry, biology, immunology, or a related field.
  • 10+ years’ experience working in the pharmaceutical/biotechnology industry, with a focus on regulated bioanalysis.
  • Demonstrated bioanalysis expertise for protein drugs, ADA, and biomarkers with excellent tracked records is required.
  • Hands-on experience in developing and validating ligand binding assays is required. 
  • In-depth knowledge of GLP/GCP regulations.
  • Experience generating cell lines and working on cell-based bioanalytical assays (e.g., neutralizing antibody assays) is desired.
  • Experience working with relevant functions/CROs to generate critical reagents to support immunoassays is a plus.

Disc Medicine is an equal opportunity employer committed to providing all qualified candidates and employees equal opportunities.  Disc Medicine actively recruits individuals with an entrepreneurial spirit and a drive for excellence.  The Company headquarters are in Watertown, MA, and we offer a flexible work environment, comprehensive benefits, and competitive compensation packages.

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